Lamesticumin G, a new α-glucosidase inhibitor from the fruit peels of Lansium parasiticum

Nat Prod Res. 2018 Aug;32(16):1881-1886. doi: 10.1080/14786419.2017.1354184. Epub 2017 Jul 19.

Abstract

A novel onoceranoid triterpene, named lamesticumin G (1) along with four known compounds (2-5) were isolated from the ethyl acetate extract of the fruit peels of Lansium parasiticum. The structure of lamesticumin G (1) was fully characterised using spectroscopic data. Lamesticumin G (1) inhibited α-glucosidase (maltase) with IC50 value of 2.27 mM, while 2-5 showed no inhibition.

Keywords: Lamesticumin G; Lansium parasiticum; Meliaceae; diabetes; onoceranoid; triterpenoid; α-glucosidase.

MeSH terms

  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Fruit / chemistry*
  • Glycoside Hydrolase Inhibitors / chemistry*
  • Meliaceae / chemistry*
  • Molecular Structure
  • Plant Extracts / chemistry
  • Triterpenes / chemistry*
  • alpha-Glucosidases / drug effects

Substances

  • Enzyme Inhibitors
  • Glycoside Hydrolase Inhibitors
  • Plant Extracts
  • Triterpenes
  • lamesticumin G
  • alpha-Glucosidases