Near infrared quantum dots in biomedical applications: current status and future perspective

Peng Zhao; Quan Xu; Jia Tao; Zongwen Jin; Yue Pan; Changmin Yu; Zhiqiang Yu

doi:10.1002/wnan.1483

Near infrared quantum dots in biomedical applications: current status and future perspective

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018 May;10(3):e1483. doi: 10.1002/wnan.1483. Epub 2017 Jul 18.

Authors

Peng Zhao^{1

2}, Quan Xu³, Jia Tao^{2

4}, Zongwen Jin⁵, Yue Pan⁶, Changmin Yu⁷, Zhiqiang Yu^{1

2}

Affiliations

¹ School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.
² State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, China.
³ State Key Laboratory of Heavy Oil Processing, China University of Petroleum (Beijing), Beijing, China.
⁴ School of Chemistry and Engineering, South China University of Technology, Guangzhou, China.
⁵ Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
⁶ State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China.
⁷ College of Materials Science & Engineering, South China University of Technology, Guangzhou, China.

PMID: 28719080
DOI: 10.1002/wnan.1483

Abstract

To address the requirements of biomedical applications including biosensing, bioimaging, and drug delivery, fluorescent nanomaterials served as efficient tools in many cases. Among them, near-infrared quantum dots (NIR QDs) have been used as novel fluorescent labels for their binary advantages of both QDs and NIR light. In this review, through collecting references in recent 10 years, we have introduced basic structures and properties of NIR QDs and summarized the classification and the related synthetic methods. This review also highlights the functionalization and surface bioconjugation of NIR QDs, and their biomedical applications in biosensing, bioimaging, and drug delivery. This article is categorized under: Diagnostic Tools > Diagnostic Nanodevices Diagnostic Tools > In Vitro Nanoparticle-Based Sensing Diagnostic Tools > In Vivo Nanodiagnostics and Imaging.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Drug Delivery Systems*
Fluorescent Dyes
Humans
Mice
Quantum Dots*
Spectroscopy, Near-Infrared*
Theranostic Nanomedicine*

Substances

Fluorescent Dyes