Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls

Insa Korten; Margot Liechti; Florian Singer; Gaudenz Hafen; Isabelle Rochat; Pinelopi Anagnostopoulou; Dominik Müller-Suter; Jakob Usemann; Alexander Moeller; Urs Frey; Philipp Latzin; Carmen Casaulta; SCILD and BILD study group

doi:10.1016/j.jcf.2017.05.005

Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls

J Cyst Fibros. 2018 Jan;17(1):105-108. doi: 10.1016/j.jcf.2017.05.005. Epub 2017 Jul 14.

Affiliations

¹ Paediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, Switzerland; University Children's Hospital (UKBB), Basel, Switzerland.
² Paediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland.
³ Paediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland; Division of Respiratory Medicine, University Children's Hospital Zurich, Switzerland.
⁴ Department of Paediatrics, Respiratory Unit, Lausanne University Hospital, Lausanne, Switzerland.
⁵ Division of Respiratory Medicine, Children's Hospital Aarau, Switzerland.
⁶ Paediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland; University Children's Hospital (UKBB), Basel, Switzerland.
⁷ Division of Respiratory Medicine, University Children's Hospital Zurich, Switzerland.
⁸ University Children's Hospital (UKBB), Basel, Switzerland.
⁹ Paediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland. Electronic address: carmen.casaulta@insel.ch.

PMID: 28716479
DOI: 10.1016/j.jcf.2017.05.005

Abstract

Exhaled nitric oxide (FE_NO) is a well-known, non-invasive airway biomarker. In patients with Cystic Fibrosis (CF) FE_NO is decreased. To understand if reduced FE_NO is primary related to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) dysfunction or an epiphenomenon of chronic inflammation, we measured FE_NO in 34 infants with CF prior to clinical symptoms and in 68 healthy controls. FE_NO was lower in CF compared to controls (p=0.0006) and the effect was more pronounced in CF infants without residual CFTR function (p<0.0001). This suggests that FE_NO is reduced in CF early in life, possibly associated with underlying CFTR dysfunction.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asymptomatic Diseases
Biomarkers / analysis
Biomarkers / metabolism
Breath Tests / methods*
Cohort Studies
Cystic Fibrosis Transmembrane Conductance Regulator / metabolism*
Cystic Fibrosis* / diagnosis
Cystic Fibrosis* / metabolism
Exhalation
Female
Humans
Infant
Inflammation / metabolism
Male
Nitric Oxide* / analysis
Nitric Oxide* / metabolism
Switzerland

Substances

Biomarkers
Cystic Fibrosis Transmembrane Conductance Regulator
Nitric Oxide