De novo telomere addition at chromosome breaks: Dangerous Liaisons

Dmitri Churikov; Vincent Géli

doi:10.1083/jcb.201705156

De novo telomere addition at chromosome breaks: Dangerous Liaisons

J Cell Biol. 2017 Aug 7;216(8):2243-2245. doi: 10.1083/jcb.201705156. Epub 2017 Jul 14.

Authors

Dmitri Churikov^{1

2}, Vincent Géli^{3

2}

Affiliations

¹ Marseille Cancer Research Center, U1068 Institut National de la Santé et de la Recherche Médicale, UMR7258 Centre National de la Recherche Scientifique, Aix Marseille University, Marseille, France.
² Institut Paoli-Calmettes, Marseille, France.
³ Marseille Cancer Research Center, U1068 Institut National de la Santé et de la Recherche Médicale, UMR7258 Centre National de la Recherche Scientifique, Aix Marseille University, Marseille, France vincent.geli@inserm.fr.

Abstract

Telomerase counteracts the loss of terminal DNA sequences from chromosome ends; however, it may erroneously add telomeric repeats to DNA double-strand breaks. In this issue, Ouenzar et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610071) uncover cell cycle-dependent sequestration of the telomerase RNA in nucleoli, a process that excludes telomerase from DNA repair sites.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Chromosome Breakage*
DNA Breaks, Double-Stranded
DNA Repair
Telomerase / genetics
Telomere*
Telomere-Binding Proteins / genetics

Substances

Telomere-Binding Proteins
Telomerase