Case study: Reinforcement of 45S5 bioglass robocast scaffolds by HA/PCL nanocomposite coatings

Azadeh Motealleh; Siamak Eqtesadi; Antonia Pajares; Pedro Miranda; David Salamon; Klara Castkova

doi:10.1016/j.jmbbm.2017.07.012

Case study: Reinforcement of 45S5 bioglass robocast scaffolds by HA/PCL nanocomposite coatings

J Mech Behav Biomed Mater. 2017 Nov:75:114-118. doi: 10.1016/j.jmbbm.2017.07.012. Epub 2017 Jul 8.

Authors

Azadeh Motealleh¹, Siamak Eqtesadi¹, Antonia Pajares¹, Pedro Miranda², David Salamon³, Klara Castkova³

Affiliations

¹ Departamento de Ingeniería Mecánica, Energética y de los Materiales, Universidad de Extremadura, Escuela de Ingenierías Industriales, Avda. de Elvas s/n, 06006 Badajoz, Spain.
² Departamento de Ingeniería Mecánica, Energética y de los Materiales, Universidad de Extremadura, Escuela de Ingenierías Industriales, Avda. de Elvas s/n, 06006 Badajoz, Spain. Electronic address: pmiranda@unex.es.
³ CEITEC - Central European Institute of Technology, Brno University of Technology, Purkynova 123, Brno 61200, Czech Republic.

PMID: 28709035
DOI: 10.1016/j.jmbbm.2017.07.012

Abstract

The purpose of this study is to analyze the mechanical enhancement provided by nanocomposite coatings deposited on robocast 45S5 bioglass (BG) scaffolds for bone tissue regeneration. In particular, a nanocomposite layer consisting of hydroxyapatite (HA) nanoparticles, as reinforcing phase, in a polycaprolactone (PCL) matrix was deposited onto the surface of the BG struts conforming the scaffold. Three different HA nanopowders were used in this study. The effect of particle size and morphology of these HA nanopowders on the mechanical performance of 45S5 BG scaffolds is evaluated.

Keywords: 45S5 BG scaffolds; Coating; HA nanoparticles; Mechanical properties.

MeSH terms

Ceramics / analysis*
Durapatite / analysis*
Glass / analysis*
Materials Testing
Nanocomposites / analysis*
Polyesters
Tissue Engineering
Tissue Scaffolds*

Substances

Polyesters
bioactive glass 45S5
polycaprolactone
Durapatite