Regulation of calcium and magnesium homeostasis in plants: from transporters to signaling network

Abstract

Calcium (Ca²⁺) and magnesium (Mg²⁺) are the most abundant divalent cations in plants. As a nutrient and a signaling ion, Ca²⁺ levels in the cell are tightly controlled by an array of channels and carriers that provide mechanistic basis for Ca²⁺ homeostasis and the generation of Ca²⁺ signals. Although a family of CorA-type Mg²⁺ transporters plays a key role in controlling Mg²⁺ homeostasis in plants, more components are yet to be identified. Ca²⁺ and Mg²⁺ appear to have antagonistic interactions in plant cells, and therefore plants depend on a homeostatic balance between Ca²⁺ and Mg²⁺ for optimal growth and development. Maintenance of such a balance in response to changing nutrient status in the soil emerges as a critical feature of plant mineral nutrition. Studies have uncovered signaling mechanisms that perceive nutrient status as a signal and regulate transport activities as adaptive responses. This 'nutrient sensing' network is exemplified by the Ca²⁺-dependent CBL (calcineurin B-like)-CIPK (CBL-interacting protein kinase) pathway that serves as a major link between environmental nutrient status and transport activities. In this review, we analyze the recent literature on Ca²⁺ and Mg²⁺ transport systems and their regulation and provide our perspectives on future research.