Dear colleagues, It is a pleasure to introduce you to the 2nd issue of UIO in 2017, demonstrating, again, the wide applications and promising developments in ultrasonography. The issue starts with a special editorial from Ioan Sporea from Romania, very well known for his scientific work on the clinical significance of elastography. Dr. Sporea outlines the central role of modern sonographic techniques for clinical decision making in modern hepatology. Together with the great advances in the treatment of chronic viral hepatitis, ultrasonography with elastography and CEUS as a "one stop shopping" facility may give us all the information we need to proceed to treatment, thus superseding liver biopsy in many (though definitively not all) patients with liver disease.