Draft Genome Sequences of Three Actinobacteria Strains Presenting New Candidate Organisms with High Potentials for Specific P450 Cytochromes

Christian Grumaz; Yevhen Vainshtein; Philipp Kirstahler; Stephan Luetz; Matthias Kittelmann; Kirsten Schroer; Fabian K Eggimann; Rico Czaja; Andreas Vogel; Thomas Hilberath; Anne Worsch; Marco Girhard; Vlada B Urlacher; Marcel Sandberg; Kai Sohn

doi:10.1128/genomeA.00532-17

Draft Genome Sequences of Three Actinobacteria Strains Presenting New Candidate Organisms with High Potentials for Specific P450 Cytochromes

Genome Announc. 2017 Jul 13;5(28):e00532-17. doi: 10.1128/genomeA.00532-17.

Authors

Affiliations

¹ Department of Molecular Biotechnology, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Stuttgart, Germany christian.grumaz@igb.fraunhofer kai.sohn@igb.fraunhofer.de.
² Department of Molecular Biotechnology, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Stuttgart, Germany.
³ Novartis Pharma AG, Novartis Institutes of Biomedical Research, Basel, Switzerland.
⁴ c-LEcta GmbH, Leipzig, Germany.
⁵ Heinrich Heine University, Institute of Biochemistry, Düsseldorf, Germany.
⁶ Kappa Bioscience, Oslo, Norway.

Abstract

The three Actinobacteria strains Streptomyces platensis DSM 40041, Pseudonocardia autotrophica DSM 535, and Streptomyces fradiae DSM 40063 were described to selectively oxyfunctionalize several drugs. Here, we present their draft genomes to unravel their gene sets encoding promising cytochrome P450 monooxygenases associated with the generation of drug metabolites.