MnCl2 -Catalyzed C-H Alkylations with Alkyl Halides

Abstract

C-H alkylations with challenging β-hydrogen-containing alkyl halides were accomplished with sustainable MnCl₂ as the catalyst under phosphine-ligand-free conditions. The proximity-induced benzamide C-H activation occurred with ample substrate scope through rate-determining C-H metalation, also setting the stage for manganese-catalyzed oxidative C-H methylations.

Keywords: C−H activation; alkylation; manganese; mechanism; selectivity.