Development of antifungal therapies using nanomaterials

Nanomedicine (Lond). 2017 Aug;12(15):1891-1905. doi: 10.2217/nnm-2017-0052. Epub 2017 Jul 13.

Abstract

The number and diversity of chemical structures currently available as antibacterial drugs is much higher compared with the number of active substances in relation to pathogenic fungi. In this review we focus on nanotechnology approaches, which offer promising strategies to create nanoagents that possess broad-spectrum antifungal activity and might overcome mechanisms of antibiotic resistance. Special attention was given to magnetic nanoparticles and their ability to restrict fungal growth directly, which depends on surface chemistry and pathogen strains. We speculate that future developments of new antifungal methods will take advantage of the current knowledge of using of magnetic nanomaterials as anticancer agents based on their ability to induce hyperthermia and enhance photosensitizing processes.

Keywords: antibiotic resistance; antifungal; magnetic nanoparticles.

Publication types

  • Review

MeSH terms

  • Animals
  • Antifungal Agents / chemistry*
  • Antifungal Agents / pharmacology*
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Drug Resistance, Fungal
  • Fungi / drug effects
  • Humans
  • Magnetite Nanoparticles / chemistry*
  • Nanomedicine
  • Particle Size
  • Surface Properties

Substances

  • Antifungal Agents
  • Antineoplastic Agents
  • Magnetite Nanoparticles