Electrochemical synthesis of phthalides via anodic activation of aromatic carboxylic acids

Davit Hayrapetyan; Viacheslav Shkepu; Olzhas T Seilkhanov; Zhaisan Zhanabil; Kevin Lam

doi:10.1039/c7cc03669h

Electrochemical synthesis of phthalides via anodic activation of aromatic carboxylic acids

Chem Commun (Camb). 2017 Jul 25;53(60):8451-8454. doi: 10.1039/c7cc03669h.

Authors

Davit Hayrapetyan¹, Viacheslav Shkepu¹, Olzhas T Seilkhanov², Zhaisan Zhanabil¹, Kevin Lam³

Affiliations

¹ Department of Chemistry, Nazarbayev University, 53 Kabanbay Batyr Avenue, 010 000 Astana, Republic of Kazakhstan. kevin.lam@nu.edu.kz.
² Laboratory of Engineering Profile NMR Spectroscopy Sh. Ualikhanov Kokshetau State University, Abay Str., 76, 020000 Kokshetau, Republic of Kazakhstan.
³ Department of Pharmaceutical, Chemical and Environmental Sciences, Faculty of Engineering and Science, University of Greenwich, Central Avenue, Chatham Maritime, Chatham, Kent ME4 4TB, UK. k.lam@greenwich.ac.uk and Department of Chemistry, Nazarbayev University, 53 Kabanbay Batyr Avenue, 010 000 Astana, Republic of Kazakhstan. kevin.lam@nu.edu.kz.

PMID: 28702553
DOI: 10.1039/c7cc03669h

Abstract

A novel electrochemical synthesis of phthalides was successfully developed using anodically generated aroyloxy radicals in combination with aliphatic carboxylic acid as cheap and readily available alkylating agent precursors.