Pd(II)/Bipyridine-Catalyzed Conjugate Addition of Arylboronic Acids to α,β-Unsaturated Carboxylic Acids. Synthesis of β-Quaternary Carbons Substituted Carboxylic Acids

Rui Liu; Zhenyu Yang; Yuxin Ni; Kaixuan Song; Kai Shen; Shaohui Lin; Qinmin Pan

doi:10.1021/acs.joc.7b01248

Pd(II)/Bipyridine-Catalyzed Conjugate Addition of Arylboronic Acids to α,β-Unsaturated Carboxylic Acids. Synthesis of β-Quaternary Carbons Substituted Carboxylic Acids

J Org Chem. 2017 Aug 4;82(15):8023-8030. doi: 10.1021/acs.joc.7b01248. Epub 2017 Jul 24.

Authors

Rui Liu¹, Zhenyu Yang¹, Yuxin Ni¹, Kaixuan Song¹, Kai Shen¹, Shaohui Lin¹, Qinmin Pan¹

Affiliation

¹ State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Key Laboratory of Organic Synthesis of Jiangsu Province, Green Polymer and Catalysis Technology Laboratory (GAPCT), College of Chemistry, Chemical Engineering and Materials Science, Soochow University , 199 Ren'ai Road, Suzhou 215123, P. R. China.

PMID: 28699747
DOI: 10.1021/acs.joc.7b01248

Abstract

Pd(II)/bipyridine-catalyzed conjugate addition of arylboronic acids to α,β-unsaturated carboxylic acids (including β,β-disubstituted acrylic acids) was developed and optimized, which provided a mild and convenient method for the highly challenging synthesis of β-quaternary carbons substituted carboxylic acids.

Publication types

Research Support, Non-U.S. Gov't