Sub-therapeutic darunavir concentration and garlic consumption; a «Mediterranean» drug-food interaction, about 2 cases

N Cloarec; C Solas; A Ladaique; C Tamalet; O Zaegel-Faucher; S Bregigeon; B Canet; C E Cano; Isabelle Poizot-Martin

doi:10.1007/s00228-017-2300-9

Sub-therapeutic darunavir concentration and garlic consumption; a «Mediterranean» drug-food interaction, about 2 cases

Eur J Clin Pharmacol. 2017 Oct;73(10):1331-1333. doi: 10.1007/s00228-017-2300-9. Epub 2017 Jul 11.

Authors

N Cloarec^{1

2}, C Solas^{1

3

4}, A Ladaique^{1

3}, C Tamalet^{1

5

6}, O Zaegel-Faucher^{1

2}, S Bregigeon^{1

2}, B Canet^{1

2}, C E Cano^{1

2

7}, Isabelle Poizot-Martin^{8

9

10}

Affiliations

¹ Aix-Marseille University, Marseille, France.
² APHM- Sainte-Marguerite Hospital, Department of Immuno-Haematology/HIV, Aix-Marseille University, 13274, Marseille, France.
³ Laboratoire de Pharmacocinétique et Toxicologie, APHM-Timone Hospital, 13385, Marseille, France.
⁴ INSERM U-911 CRO2, Marseille, France.
⁵ APHM-Timone Hospital, Fédération de Microbiologie Hospitalière, Marseille, France.
⁶ URMITE CNRS-IRDUMR6236, Marseille, France.
⁷ INSERM U-912 (SESSTIM), Aix-Marseille University, Marseille, France.
⁸ Aix-Marseille University, Marseille, France. isabelle.poizot@ap-hm.fr.
⁹ APHM- Sainte-Marguerite Hospital, Department of Immuno-Haematology/HIV, Aix-Marseille University, 13274, Marseille, France. isabelle.poizot@ap-hm.fr.
¹⁰ INSERM U-912 (SESSTIM), Aix-Marseille University, Marseille, France. isabelle.poizot@ap-hm.fr.

PMID: 28699073
DOI: 10.1007/s00228-017-2300-9

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Adult
Darunavir / administration & dosage
Darunavir / pharmacokinetics*
Female
Food-Drug Interactions*
Garlic / chemistry*
HIV Infections / drug therapy
HIV Protease Inhibitors / administration & dosage
HIV Protease Inhibitors / pharmacokinetics*
Humans
Male

Substances

HIV Protease Inhibitors
Darunavir