Enhancing the alignment of the preclinical and clinical stroke recovery research pipeline: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable translational working group

Dale Corbett; S Thomas Carmichael; Timothy H Murphy; Theresa A Jones; Martin E Schwab; Jukka Jolkkonen; Andrew N Clarkson; Numa Dancause; Tadeusz Wieloch; Heidi Johansen-Berg; Michael Nilsson; Louise D McCullough; Mary T Joy

doi:10.1177/1747493017711814

Enhancing the alignment of the preclinical and clinical stroke recovery research pipeline: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable translational working group

Int J Stroke. 2017 Jul;12(5):462-471. doi: 10.1177/1747493017711814.

Authors

Dale Corbett¹, S Thomas Carmichael², Timothy H Murphy³, Theresa A Jones⁴, Martin E Schwab^{5

6}, Jukka Jolkkonen⁷, Andrew N Clarkson^{8

9}, Numa Dancause¹⁰, Tadeusz Wieloch¹¹, Heidi Johansen-Berg¹², Michael Nilsson¹³, Louise D McCullough¹⁴, Mary T Joy¹⁵

Affiliations

¹ 1 Department of Cellular and Molecular Medicine, University of Ottawa, Canadian Partnership for Stroke Recovery, Ottawa, Canada.
² 2 Department of Neurology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA.
³ 3 Department of Psychiatry, Kinsmen Laboratory of Neurological Research, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.
⁴ 4 Department of Psychology and Neuroscience Institute, University of Texas at Austin, Austin, TX, USA.
⁵ 5 Institute for Brain Research, University of Zurich.
⁶ 6 Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
⁷ 7 Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland and Neurocenter, Neurology, University Hospital of Kuopio, Kuopio, Finland.
⁸ 8 Department of Anatomy, Brain Health Research Center, and Brain Research New Zealand, University of Otago, Dunedin, New Zealand.
⁹ 9 Faculty of Pharmacy, The University of Sydney, Sydney, Australia.
¹⁰ 10 Groupe de Recherche sur le Système Nerveux central (GRSNC), Département de Neurosciences, Université de Montréal, Montréal, Canada.
¹¹ 11 Department of Clinical Sciences, Laboratory for Experimental Brain Research, Lund, Sweden.
¹² 12 Oxford Centre for Functional MRI of the Brain, John Radcliffe Hospital, Headington, Oxford, UK.
¹³ 13 Hunter Medical Research Institute, University of Newcastle, New Lambton, Australia.
¹⁴ 14 Department of Neurology, University of Texas Health Sciences Center at Houston, Houston, TX, USA.
¹⁵ 15 Department of Neurology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA.

PMID: 28697710
DOI: 10.1177/1747493017711814

Abstract

Stroke recovery research involves distinct biological and clinical targets compared to the study of acute stroke. Guidelines are proposed for the pre-clinical modeling of stroke recovery and for the alignment of pre-clinical studies to clinical trials in stroke recovery.

Keywords: Rehabilitation; consensus; neurorecovery; neurorehabilitation; stroke; stroke recovery; translational medicine.

Publication types

Consensus Development Conference

MeSH terms

Animals
Brain / diagnostic imaging
Brain / physiopathology
Humans
Motor Activity / physiology
Recovery of Function* / physiology
Sensation / physiology
Stroke / diagnostic imaging
Stroke / physiopathology*
Stroke Rehabilitation
Translational Research, Biomedical* / methods