A Novel Tropoloisoquinoline Alkaloid, Neotatarine, from Acorus calamus L

Chem Biodivers. 2017 Oct;14(10). doi: 10.1002/cbdv.201700201. Epub 2017 Oct 4.

Abstract

A novel tropoloisoquinoline alkaloid, neotatarine (1), was isolated from the 95% ethanol extract of the rhizome parts of Acorus calamus L. The chemical structure was unambiguously elucidated by spectroscopic and single-crystal X-ray diffraction analysis. Neotatarine (1) exhibited significantly inhibitory activity against Aβ25 - 35 induced PC12 cell death with 2, 4 and 8 μm comparing with the assay control (P < 0.01).

Keywords: 7H-Azuleno[1,2,3-ij]isoquinolin-7-one; Acorus calamus L.; Araceae; PC12 cells; Tropoloisoquinoline alkaloid.

MeSH terms

  • Acorus / chemistry*
  • Amyloid beta-Peptides / antagonists & inhibitors*
  • Animals
  • Cell Death / drug effects
  • Cell Survival / drug effects
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Isoquinolines / chemistry
  • Isoquinolines / isolation & purification
  • Isoquinolines / pharmacology*
  • Molecular Structure
  • PC12 Cells
  • Peptide Fragments / antagonists & inhibitors*
  • Rats
  • Structure-Activity Relationship
  • Tropolone / analogs & derivatives*
  • Tropolone / chemistry
  • Tropolone / isolation & purification
  • Tropolone / pharmacology

Substances

  • Amyloid beta-Peptides
  • Isoquinolines
  • Peptide Fragments
  • amyloid beta-protein (25-35)
  • neotatarine
  • Tropolone