Abstract
A novel tropoloisoquinoline alkaloid, neotatarine (1), was isolated from the 95% ethanol extract of the rhizome parts of Acorus calamus L. The chemical structure was unambiguously elucidated by spectroscopic and single-crystal X-ray diffraction analysis. Neotatarine (1) exhibited significantly inhibitory activity against Aβ25 - 35 induced PC12 cell death with 2, 4 and 8 μm comparing with the assay control (P < 0.01).
Keywords:
7H-Azuleno[1,2,3-ij]isoquinolin-7-one; Acorus calamus L.; Araceae; PC12 cells; Tropoloisoquinoline alkaloid.
© 2017 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
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Acorus / chemistry*
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Amyloid beta-Peptides / antagonists & inhibitors*
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Animals
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Cell Death / drug effects
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Cell Survival / drug effects
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Cells, Cultured
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Dose-Response Relationship, Drug
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Isoquinolines / chemistry
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Isoquinolines / isolation & purification
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Isoquinolines / pharmacology*
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Molecular Structure
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PC12 Cells
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Peptide Fragments / antagonists & inhibitors*
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Rats
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Structure-Activity Relationship
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Tropolone / analogs & derivatives*
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Tropolone / chemistry
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Tropolone / isolation & purification
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Tropolone / pharmacology
Substances
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Amyloid beta-Peptides
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Isoquinolines
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Peptide Fragments
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amyloid beta-protein (25-35)
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neotatarine
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Tropolone