The southerly Great Plains low-level jet (GPLLJ) is one of the most significant circulation features of the central U.S. linking large-scale atmospheric circulation with the regional climate. GPLLJs transport heat and moisture, contribute to thunderstorm and severe weather formation, provide a corridor for the springtime migration of birds and insects, enhance wind energy availability, and disperse air pollution. We assess future changes in GPLLJ frequency using an eight member ensemble of dynamically-downscaled climate simulations for the mid-21st century. Nocturnal GPLLJ frequency is projected to increase in the southern plains in spring and in the central plains in summer, whereas current climatological patterns persist into the future for daytime and cool season GPLLJs. The relationship between future GPLLJ frequency and the extent and strength of anticyclonic airflow over eastern North America varies with season. Most simulations project a westward shift of anticyclonic airflow in summer, but uncertainty is larger for spring with only half of the simulations suggesting a westward expansion. The choice of regional climate model and the driving lateral boundary conditions have a large influence on the projected future changes in GPLLJ frequency and highlight the importance of multi-model ensembles to estimate the uncertainty surrounding the future GPLLJ climatology.