HHV8 and Kaposi's sarcoma: should we really give up protease inhibitors in all HIV-infected patients?

AIDS. 2017 Sep 24;31(15):2167-2169. doi: 10.1097/QAD.0000000000001588.

Abstract

: We describe the first case of a patient presenting Kaposi's sarcoma with human herpes virus 8 (HHV8) viremia after switching from a protease inhibitor to an integrase inhibitor-based combination antiretroviral therapy, followed by a rapid remission when resuming protease inhibitor. We suggest that the recent recommendations to switch all HIV patients to protease inhibitor-free regimens should be carefully re-evaluated especially in MSM HIV patients which are at higher risks of HHV8 infections and associated malignancies.

Publication types

  • Case Reports

MeSH terms

  • Antiretroviral Therapy, Highly Active / methods*
  • Drug Substitution
  • HIV Infections / complications*
  • HIV Infections / drug therapy*
  • HIV Integrase Inhibitors / therapeutic use*
  • HIV Protease Inhibitors / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Sarcoma, Kaposi / diagnosis*
  • Sarcoma, Kaposi / pathology*

Substances

  • HIV Integrase Inhibitors
  • HIV Protease Inhibitors