15-deoxy-isoxeniolide-A, new diterpenoid from a bornean soft coral, Xenia sp

Chin-Soon Phan; Takashi Kamada; Kazushi Kobayashi; Toshiyuki Hamada; Charles Santhanaraju Vairappan

doi:10.1080/14786419.2017.1346638

15-deoxy-isoxeniolide-A, new diterpenoid from a bornean soft coral, Xenia sp

Nat Prod Res. 2018 Jan;32(2):202-207. doi: 10.1080/14786419.2017.1346638. Epub 2017 Jul 10.

Authors

Chin-Soon Phan¹, Takashi Kamada¹, Kazushi Kobayashi², Toshiyuki Hamada², Charles Santhanaraju Vairappan

Affiliations

¹ a Laboratory of Natural Products Chemistry , Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah , Sabah , Malaysia.
² b Graduate School of Science and Engineering , Kagoshima University , Kagoshima , Japan.

PMID: 28691521
DOI: 10.1080/14786419.2017.1346638

Abstract

A new xenicane diterpenoid, 15-deoxy-isoxeniolide-A (1) along with four known compounds 9-deoxy-isoxeniolide-A (2), isoxeniolide-A (3), xeniolide-A (4) and coraxeniolide-B (5) were isolated from the Bornean soft coral Xenia sp. The structures of these metabolites were elucidated on the basis of spectral analysis, NMR and HRESIMS. Compound 5 showed cytotoxic activity against ATL cell line, S1T.

Keywords: S1T; Soft coral; Xenia sp.; adult T-cell leukaemia; diterpene; xenicane.

MeSH terms

Animals
Anthozoa / chemistry*
Anthozoa / metabolism
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Diterpenes / chemistry*
Drug Evaluation, Preclinical / methods
Drug Screening Assays, Antitumor / methods
Humans
Leukemia, T-Cell / drug therapy
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure

Substances

Anti-Bacterial Agents
Antineoplastic Agents
Diterpenes