Transcatheter Aortic Valve Implantation in Nonagenarians: Procedural Outcome and Mid-Term Results

Heart Lung Circ. 2018 Jun;27(6):725-730. doi: 10.1016/j.hlc.2017.05.137. Epub 2017 Jun 15.

Abstract

Background: For nonagenarians with symptomatic severe aortic stenosis transcatheter aortic valve implantation (TAVI) has become a feasible therapeutic option. Therefore, the aim of this study was to evaluate the procedural outcomes and mid-term follow-up in this patient group and compare this to octogenarians.

Methods: From 1359 patients who underwent TAVI at our institution between March 2009 and February 2016, 82 patients were nonagenarians and 912 were octogenarians. In nonagenarians, mean age was 91.9±1.4years and compared to octogenarians showed a significantly higher logistic EuroScore (27.7±14.8% vs. 23.1±14.4, p=0.005) and STS Score (8.5±4.8% vs. 6.3±6.7, p=0.001).

Results: There were no significant differences with regard to stroke rate, pacemaker implantation rate and major vascular complications between the two groups. Thirty-day mortality was 9.8% in nonagenarians and 4.1% in octogenarians (p=0.04). At 1 year, all-cause mortality increased to 30.9% vs. 18.6% (n.s.).

Conclusion: Nonagenarians showed an increased periprocedural mortality during TAVI and higher mortality in follow-up compared to octogenarians. Age alone is not a predictive factor but indication for treatment should be carefully evaluated by the heart team on an individual basis.

Keywords: Aortic stenosis; Nonagenarians; TAVI.

Publication types

  • Comparative Study
  • Multicenter Study
  • Observational Study

MeSH terms

  • Age Factors
  • Aged, 80 and over
  • Aortic Valve / diagnostic imaging
  • Aortic Valve / surgery*
  • Aortic Valve Stenosis / diagnosis
  • Aortic Valve Stenosis / mortality
  • Aortic Valve Stenosis / surgery*
  • Coronary Angiography
  • Echocardiography
  • Female
  • Follow-Up Studies
  • Germany / epidemiology
  • Humans
  • Male
  • Multidetector Computed Tomography / methods
  • Prognosis
  • Prosthesis Design
  • Retrospective Studies
  • Risk Factors
  • Severity of Illness Index
  • Survival Rate / trends
  • Time Factors
  • Transcatheter Aortic Valve Replacement / methods*