Subtractional Heterogeneity: A Crucial Step toward Defining Specialized Ribosomes

Joseph W Briggs; Jonathan D Dinman

doi:10.1016/j.molcel.2017.06.022

Subtractional Heterogeneity: A Crucial Step toward Defining Specialized Ribosomes

Mol Cell. 2017 Jul 6;67(1):3-4. doi: 10.1016/j.molcel.2017.06.022.

Authors

Joseph W Briggs¹, Jonathan D Dinman²

Affiliations

¹ Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA.
² Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA. Electronic address: dinman@umd.edu.

Abstract

In this issue of Molecular Cell, Shi et al. (2017) identify translating ribosomes which lack specific proteins and associate with specific classes of mRNAs. This challenges the popular conception of "the ribosome" as a homogeneous, monolithic molecular machine.

MeSH terms

Humans
Protein Biosynthesis
RNA, Messenger*
Ribosomes*

Substances

RNA, Messenger

Grants and funding

R01 GM117177/GM/NIGMS NIH HHS/United States