The aCCR(2)ual of M2 Macrophages Provides Some Breathing Room

Preethi Vijayaraj; Brigitte N Gomperts

doi:10.1016/j.stem.2017.06.006

The aCCR(2)ual of M2 Macrophages Provides Some Breathing Room

Cell Stem Cell. 2017 Jul 6;21(1):1-3. doi: 10.1016/j.stem.2017.06.006.

Authors

Preethi Vijayaraj¹, Brigitte N Gomperts²

Affiliations

¹ UCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA.
² UCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA; Eli and Edythe Broad Stem Cell Research Center, UCLA, Los Angeles, CA 90095, USA; UCLA Molecular Biology Institute, Los Angeles, CA 90095, USA. Electronic address: bgomperts@mednet.ucla.edu.

PMID: 28686859
DOI: 10.1016/j.stem.2017.06.006

Abstract

Lung tissue can robustly regenerate functional alveolar units after injury, but the mechanisms are unknown. Lechner et al. (2017) in this issue of Cell Stem Cell demonstrate that lung regeneration is facilitated by bone-marrow-derived myeloid cells that are recruited to the lung through a CCL2-CCR2 chemokine axis and by IL-13 expressing innate lymphoid cells.

Publication types

Review

MeSH terms

Animals
Chemokine CCL2 / immunology*
Humans
Interleukin-13 / immunology
Lung / physiology*
Lung Injury / immunology*
Lung Injury / pathology
Macrophages, Alveolar / immunology*
Macrophages, Alveolar / pathology
Receptors, CCR2 / immunology*
Regeneration / immunology*

Substances

CCL2 protein, human
CCR2 protein, human
Chemokine CCL2
Interleukin-13
Receptors, CCR2