Is Taurine A Biomarker?

Abstract

Taurine, a sulfur-containing amino acid present in high concentrations in mammals, plays an important role in several essential biological processes. Taurine is not incorporated into protein and is the most abundant free amino acid in the heart, retina, skeletal muscle, brain, and leukocytes. The ideal biomarker or biological measure should be reliable, reproducible, noninvasive, simple to perform, and inexpensive. Samples for biological measures should be easily obtained from physiological fluids such as blood or urine. Taurine levels in physiologic fluids have been useful for both diagnosing pathology and establishing a disease modifying therapy. In the specific case of taurine, it is important that patient information include nutritional supplementation as well as information on disease status and medications. Taurine has been measured in biological fluids due to the importance of this simple amino acid and its relative ease of determination. Taurine has been measured in animal models of disease as well as a variety of human conditions. However, it remains unclear how taurine should be used as a biomarker and in which situations this measurement would be a good prognostic or diagnostic indicator.