Sterols from the Octocoral Nephthea columnaris

Ta-Yuan Whuang; Hong-Chieh Tsai; Yin-Di Su; Tsong-Long Hwang; Ping-Jyun Sung

doi:10.3390/md15070212

Sterols from the Octocoral Nephthea columnaris

Mar Drugs. 2017 Jul 4;15(7):212. doi: 10.3390/md15070212.

Authors

Ta-Yuan Whuang^{1

2}, Hong-Chieh Tsai^{3

4}, Yin-Di Su⁵, Tsong-Long Hwang^{6

7

8}, Ping-Jyun Sung^{9

10

11

12

13}

Affiliations

¹ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. xdanielzero@gmail.com.
² National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. xdanielzero@gmail.com.
³ Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. Newcomer9999@gmail.com.
⁴ Department of Neurosurgery, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. Newcomer9999@gmail.com.
⁵ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. gobetter04@gmail.com.
⁶ Graduate Institute of Natural Products, College of Medicine and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁷ Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁸ Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁹ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
¹⁰ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
¹¹ Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. pjsung@nmmba.gov.tw.
¹² Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. pjsung@nmmba.gov.tw.
¹³ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pjsung@nmmba.gov.tw.

Abstract

Two new sterols, columnaristerols B (1) and C (2), along with two known analogues, 5,6-epoxylitosterol (3) and litosterol (4), were obtained from the octocoral Nephthea columnaris. The structures of new sterols 1 and 2 were elucidated by using spectroscopic methods and comparing the spectroscopic data with those of known related metabolites. Sterol 3 was found to suppress superoxide anion production and elastase secretion by human neutrophils.

Keywords: Nephthea columnaris; columnaristerol; elastase; litosterol; octocoral; superoxide anion.

MeSH terms

Animals
Anthozoa / chemistry*
Anthozoa / metabolism
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / metabolism
Anti-Inflammatory Agents / pharmacology
Cells, Cultured
Humans
Models, Molecular
Molecular Structure
Neutrophils / drug effects*
Sterols / chemistry*
Sterols / metabolism
Sterols / pharmacology

Substances

Anti-Inflammatory Agents
Sterols