Klotho levels: association with insulin resistance and albumin-to-creatinine ratio in type 2 diabetic patients

Int Urol Nephrol. 2017 Oct;49(10):1809-1814. doi: 10.1007/s11255-017-1646-3. Epub 2017 Jul 4.

Abstract

Purpose: The present study aimed at evaluating the relationship between Klotho levels and insulin resistance and albumin-to-creatinine ratio (ACR) in type 2 diabetic patients with CKD.

Methods: We conducted an observational, cross-sectional study in our outpatient diabetic nephropathy clinic from 2014 to 2016, enrolling a total of 107 type 2 diabetic patients with stage 2-3 CKD, with a mean age of 59 years. Several clinical and laboratorial parameters were evaluated, including those related to mineral and carbohydrate metabolism.

Results: The mean eGFR at baseline was 53.2 mL/min, and the mean levels of ACR and Klotho were 181.9 µg/mg and 331.1 pg/m, respectively. In the simple linear regression model, Klotho levels were correlated with age, phosphorus, PTH, ACR, HOMA, IL-6, FGF-23, OxLDL, eGFR and vitamin D levels. Applying a multivariate linear regression model, only the ACR, HOMA-IR, FGF-23 and vitamin D independently influenced the Klotho levels. In the generalized linear model, only the Klotho groups were statistically significant as independent variable (p = 0.007). The results show that the group 1 (<268) compared with group 3 (>440) had higher odds in the higher ACR (≥181), ORa = 3.429, p = 0.014. There were no statistically significant differences between Klotho groups 2 and 3, and the HOMA-IR obtained showed that group 1 (<268) had greater odds of HOMA-IR ≥2 when compared with group 3 (>440), ORa = 21.59, p = 0.017.

Conclusions: Our results showed that Klotho levels are influenced by FGF23, vitamin D and insulin resistance. This suggests that Klotho levels might be affected by renal function as well as having a relevant role on insulin metabolism and ACR homeostasis.

Keywords: Chronic kidney disease; Diabetes; Klotho; Mineral metabolism.

Publication types

  • Observational Study

MeSH terms

  • Aged
  • Area Under Curve
  • Creatinine / blood*
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetic Nephropathies / blood*
  • Diabetic Nephropathies / physiopathology
  • Female
  • Fibroblast Growth Factor-23
  • Fibroblast Growth Factors / blood
  • Glomerular Filtration Rate
  • Glucuronidase / blood*
  • Humans
  • Insulin Resistance*
  • Klotho Proteins
  • Linear Models
  • Male
  • Middle Aged
  • ROC Curve
  • Renal Insufficiency, Chronic / blood
  • Serum Albumin / metabolism*
  • Vitamin D / blood

Substances

  • FGF23 protein, human
  • Serum Albumin
  • Vitamin D
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Creatinine
  • Glucuronidase
  • Klotho Proteins