Abstract
Alzheimer's disease is the most common form of dementia accounting for 50-60% of all dementia cases. This chapter briefly reviews the history of Alzheimer's disease and provides an overview of the clinical syndromes associated with Alzheimer pathology and their associated neuroimaging findings. This chapter also reviews the neuropathology and genetics of Alzheimer's disease and concludes by discussing current work undertaken to identify suitable in vivo biomarkers for the disease.
Keywords:
Biomarkers; Cognition; Genes; Logopenic progressive aphasia; Memory; Neuroimaging; Posterior cortical atrophy.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ATP-Binding Cassette Transporters / genetics
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Adaptor Proteins, Signal Transducing / genetics
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Alzheimer Disease / diagnostic imaging
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Alzheimer Disease / genetics
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Alzheimer Disease / pathology
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Alzheimer Disease / physiopathology*
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Amyloid beta-Protein Precursor / genetics
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Aniline Compounds
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Aphasia / physiopathology*
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Apolipoprotein E4 / genetics
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Atrophy
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Brain / diagnostic imaging
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Brain / pathology
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Brain / physiopathology*
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Cognition*
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HLA Antigens / genetics
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Humans
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Magnetic Resonance Imaging
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Memory*
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Neuroimaging
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Nuclear Proteins / genetics
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Positron-Emission Tomography
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Presenilins / genetics
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Receptors, Complement 3b / genetics
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Thiazoles
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Tomography, Emission-Computed, Single-Photon
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Tomography, X-Ray Computed
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Tumor Suppressor Proteins / genetics
Substances
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2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
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ABCA7 protein, human
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APP protein, human
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ATP-Binding Cassette Transporters
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Adaptor Proteins, Signal Transducing
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Amyloid beta-Protein Precursor
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Aniline Compounds
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Apolipoprotein E4
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BIN1 protein, human
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HLA Antigens
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Nuclear Proteins
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Presenilins
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Receptors, Complement 3b
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Thiazoles
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Tumor Suppressor Proteins