Plasmids of Diverse Inc Groups Disseminate the Fosfomycin Resistance Gene fosA3 among Escherichia coli Isolates from Pigs, Chickens, and Dairy Cows in Northeast China

Antimicrob Agents Chemother. 2017 Aug 24;61(9):e00859-17. doi: 10.1128/AAC.00859-17. Print 2017 Sep.

Abstract

Thirty-nine fosfomycin-resistant Escherichia coli isolates carrying fosA3 were obtained from pigs, chickens, dairy cows, and staff in four northeastern provinces of China between June 2015 and April 2016. The fosA3 gene was colocated with blaCTX-M genes on conjugative plasmids of the incompatibility groups IncN (n = 12), IncN-F33:A-:B-(n = 2), IncF33:A-:B-(n = 14), IncF14:A-:B-(n = 2), and IncI1/sequence type 136 (ST136) (n = 9). Four different genetic contexts of fosA3 were detected among the 39 E. coli isolates. Three potential epidemic plasmids circulated among E. coli strains from this region.

Keywords: CTX-M; antibiotic resistance; horizontal dissemination; resistance genes.

MeSH terms

  • Animals
  • Cattle
  • Chickens / microbiology
  • China
  • Drug Resistance, Bacterial / genetics*
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics*
  • Escherichia coli Infections / microbiology
  • Escherichia coli Proteins / genetics*
  • Fosfomycin / pharmacology*
  • Microbial Sensitivity Tests / methods
  • Plasmids / genetics*
  • Swine / microbiology

Substances

  • Escherichia coli Proteins
  • FosA(3) protein, E coli
  • Fosfomycin