Polymorphisms in immune-inflammatory response genes and the risk of deficit schizophrenia

Monika Mak; Błażej Misiak; Dorota Frydecka; Justyna Pełka-Wysiecka; Jolanta Kucharska-Mazur; Agnieszka Samochowiec; Przemysław Bieńkowski; Edyta Pawlak-Adamska; Lidia Karabon; Elżbieta Szmida; Paweł Skiba; Kamila Kotowicz; Patryk Piotrowski; Jan Aleksander Beszłej; Jerzy Samochowiec

doi:10.1016/j.schres.2017.06.050

Polymorphisms in immune-inflammatory response genes and the risk of deficit schizophrenia

Schizophr Res. 2018 Mar:193:359-363. doi: 10.1016/j.schres.2017.06.050. Epub 2017 Jun 30.

Authors

Affiliations

¹ Department of Psychiatry, Pomeranian Medical University, 26 Broniewski Street, 71-460 Szczecin, Poland.
² Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 50-368 Wroclaw, Poland. Electronic address: mblazej@interia.eu.
³ Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50-367 Wroclaw, Poland.
⁴ Institute of Psychology, Department of Clinical Psychology, University of Szczecin, 69 Krakowska Street, 71-017 Szczecin, Poland.
⁵ Department of Psychiatry, Medical University of Warsaw, 27 Nowowiejska Street, 00-665 Warsaw, Poland.
⁶ Department of Experimental Therapy, Laboratory of Immunopathology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Weigla Street, 51-114 Wroclaw, Poland.
⁷ Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 50-368 Wroclaw, Poland.

PMID: 28673752
DOI: 10.1016/j.schres.2017.06.050

Abstract

Polymorphisms in immune-inflammatory response genes are believed to impact schizophrenia susceptibility. However, it remains unknown whether immunogenetic factors play a role in the etiology of deficit schizophrenia (D-SCZ). Therefore, we genotyped four polymorphisms in genes encoding two immune system regulatory proteins (CTLA-4 rs231775 and CD28 rs3116496), interleukin-6 (IL6 rs1800795) and transforming growth factor-β (TGFB1 rs1800470) in 513 schizophrenia patients and 374 controls. The CD28 rs3116496-CC genotype and C-allele were significantly more frequent in the whole group of patients and D-SCZ patients compared to controls. Our results indicate that the CD28 rs3116496 polymorphism might impact the risk of schizophrenia, especially D-SCZ.

Keywords: CD28; CTLA-4; Cytokine; Deficit schizophrenia; Gene; Polymorphism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
CD28 Antigens / genetics
CTLA-4 Antigen / genetics
Cytokines / genetics*
Female
Gene Frequency
Genetic Predisposition to Disease*
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Schizophrenia / genetics*
Transforming Growth Factor beta / genetics

Substances

CD28 Antigens
CTLA-4 Antigen
Cytokines
Transforming Growth Factor beta