Abstract
Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (TH 2)-deviated immune reactions. Interleukin-31 (IL-31), preferentially produced from TH 2 cells, is a potent pruritogenic cytokine, and its systemic and local administration induces scratching behavior in rodents, dogs and monkeys. Recent clinical trials have revealed that administration of an anti-IL-31 receptor antibody significantly alleviates pruritus in patients with AD. In this review, we summarize recent topics related to IL-31 and its receptor with special references to atopic itch.
Keywords:
T helper 2; atopic dermatitis; interleukin-31; interleukin-31 receptor; pruritus.
© 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
MeSH terms
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Basic Helix-Loop-Helix Transcription Factors / genetics
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Basic Helix-Loop-Helix Transcription Factors / metabolism
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Biomarkers
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Cytokines / metabolism
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Dermatitis, Atopic / complications
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Dermatitis, Atopic / diagnosis
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Dermatitis, Atopic / etiology*
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Dermatitis, Atopic / metabolism*
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Disease Management
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Gene Expression Regulation
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Humans
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Inflammation Mediators / metabolism
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Interleukins / chemistry
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Interleukins / genetics
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Interleukins / metabolism*
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Pruritus / complications
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Pruritus / diagnosis
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Pruritus / etiology*
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Pruritus / metabolism*
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Receptors, Interleukin / chemistry
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Receptors, Interleukin / genetics
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Receptors, Interleukin / metabolism*
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Structure-Activity Relationship
Substances
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Basic Helix-Loop-Helix Transcription Factors
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Biomarkers
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Cytokines
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IL31 protein, human
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IL31RA protein, human
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Inflammation Mediators
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Interleukins
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Receptors, Interleukin
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endothelial PAS domain-containing protein 1