Many degradation processes in lithium-ion batteries are accompanied by gas evolution and therefore lead to an increase in internal cell pressure. This causes serious safety concerns for state-of-the-art lithium-ion batteries, calling for a thorough investigation of the origin and the magnitude of such processes. Herein we introduce a multichannel in situ pressure measurement system that allows for the high-throughput quantification of gas evolution under realistic battery conditions. The capability of the system was demonstrated through its application on Li4Ti5O12 half cells. The pressure changes could be divided into an irreversible and a reversible part, where the latter is caused by the deposition and dissolution of elemental lithium during cycling. Comparison of the measured and the theoretical reversible pressure changes showed a close match, indicating the high accuracy of the system. Additionally, the irreversible part observed in the pressure changes was attributed to gas evolution, as confirmed by complementary measurements using differential electrochemical mass spectrometry. To show the practicality of the system, the temperature dependence of gas evolution in Li1+xNi0.6Co0.2Mn0.2O2 full cells was investigated. Enhanced gas evolution was observed at elevated temperature, which is partly attributed to the thermal decomposition of the conducting salt LiPF6.