Modeling schizophrenia pathogenesis using patient-derived induced pluripotent stem cells (iPSCs)

Abstract

Schizophrenia is a chronic disabling mental disorder that affects about 1% population world-wide, for which there is a desperate need to develop more effective treatments. In this minireview, we summarize the findings from recent studies using induced pluripotent stem cells to model the developmental pathogenesis of schizophrenia and discuss what we have learned from these studies. We also discuss what are the important next steps and key issues to be addressed to move the field forward.

Keywords: Differentiation; Neural progenitor cell; Schizophrenia; iPSC.