Non-alcoholic fatty liver disease, to struggle with the strangle: Oxygen availability in fatty livers

Sarit Anavi; Zecharia Madar; Oren Tirosh

doi:10.1016/j.redox.2017.06.008

Non-alcoholic fatty liver disease, to struggle with the strangle: Oxygen availability in fatty livers

Redox Biol. 2017 Oct:13:386-392. doi: 10.1016/j.redox.2017.06.008. Epub 2017 Jun 22.

Authors

Sarit Anavi¹, Zecharia Madar², Oren Tirosh³

Affiliations

¹ Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Israel; Peres Academic Center, Rehovot, Israel.
² Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Israel.
³ Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Israel. Electronic address: oren.tirosh@mail.huji.ac.il.

Abstract

Nonalcoholic fatty liver diseases (NAFLD) is one of the most common chronic liver disease in Western countries. Oxygen is a central component of the cellular microenvironment, which participate in the regulation of cell survival, differentiation, functions and energy metabolism. Accordingly, sufficient oxygen supply is an important factor for tissue durability, mainly in highly metabolic tissues, such as the liver. Accumulating evidence from the past few decades provides strong support for the existence of interruptions in oxygen availability in fatty livers. This outcome may be the consequence of both, impaired systemic microcirculation and cellular membrane modifications which occur under steatotic conditions. This review summarizes current knowledge regarding the main factors which can affect oxygen supply in fatty liver.

Keywords: Fatty liver; Inflammation; Nitric oxide; Oxygen.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Liver / blood supply
Liver / metabolism*
Liver / pathology
Nitric Oxide / metabolism
Non-alcoholic Fatty Liver Disease / epidemiology
Non-alcoholic Fatty Liver Disease / metabolism*
Non-alcoholic Fatty Liver Disease / pathology
Oxygen / metabolism*
Sleep Apnea, Obstructive / epidemiology*

Substances

Nitric Oxide
Oxygen