Low IgE Is Insufficiently Sensitive to Guide Genetic Testing of STAT3 Gain-of-Function Mutations

Affiliations

• ¹ Immunology Division, Garvan Institute of Medical Research Darlinghurst, New South Wales Australia.
• ² St Vincent's Clinical School, Faculty of Medicine University of NSW, Sydney, Australia.
• ³ Section of Immunology, Allergy, & Rheumatology, Department of Pediatrics, Baylor College of Medicine, Center for Human Immunobiology, Texas Children's Hospital, Houston, TX.
• ⁴ Division of Allergy and Immunology Department of Pediatrics, University of South Florida, St Petersburg, FL.
• ⁵ Pediatric Allergy and Immunology Department Starship Children's Hospital Auckland, New Zealand.
• ⁶ Cancer and Blood Diseases Institute Division of Bone Marrow Transplantation and Immune Deficiency and Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH.
• ⁷ Department of NEUROFARBA, Section of Child's Health, University of Florence and BMT Unit, Department of Hematology-Oncology, Anna Meyer Children's Hospital, Florence Italy.
• ⁸ Genetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
• ⁹ Departments of Pediatrics, Division of Rheumatology and Department of Pathology and Immunology Washington University School of Medicine, St. Louis, MO.
• ¹⁰ Adult Immunodeficiency Unit Infectious Diseases, Inflammation Center and Rare Diseases Center Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland mikko.seppanen@hus.fi.