1 Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, Jacob.Gutsche@uphs.upenn.edu Pulmonary, Allergy, and Critical Care Division Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Division of Cardiothoracic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Department of Pharmacy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Department of Anesthesiology and Critical Care Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Departments of Anesthesiology, Mayo Hospital, Phoenix, Arizona Department of Anesthesiology and Critical Care Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Division of Cardiothoracic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Department of Anesthesiology and Critical Care Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Division of Cardiothoracic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.