The Ubiquitin System, Autophagy, and Regulated Protein Degradation

Annu Rev Biochem. 2017 Jun 20:86:123-128. doi: 10.1146/annurev-biochem-061516-044859.

Abstract

This brief disquisition about the early history of studies on regulated protein degradation introduces several detailed reviews about the ubiquitin system and autophagy.

Keywords: N-end rule; autophagy; polyubiquitin; proteasome; protein degradation; ubiquitin; ubiquitin-like.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Autophagy / genetics
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / metabolism
  • Gene Expression
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Proteasome Endopeptidase Complex / genetics
  • Proteasome Endopeptidase Complex / history
  • Proteasome Endopeptidase Complex / metabolism*
  • Proteolysis
  • Ubiquitin / genetics
  • Ubiquitin / history
  • Ubiquitin / metabolism*
  • Ubiquitin-Protein Ligase Complexes / genetics
  • Ubiquitin-Protein Ligase Complexes / history
  • Ubiquitin-Protein Ligase Complexes / metabolism*
  • Ubiquitination

Substances

  • Ubiquitin
  • Ubiquitin-Protein Ligase Complexes
  • Proteasome Endopeptidase Complex