Isoprenoids from the Soft Coral Sarcophyton glaucum

Chih-Hua Chao; Wen-Liang Li; Chiung-Yao Huang; Atallah F Ahmed; Chang-Feng Dai; Yang-Chang Wu; Mei-Chin Lu; Chih-Chuang Liaw; Jyh-Horng Sheu

doi:10.3390/md15070202

Isoprenoids from the Soft Coral Sarcophyton glaucum

Mar Drugs. 2017 Jun 27;15(7):202. doi: 10.3390/md15070202.

Authors

Chih-Hua Chao^{1

2}, Wen-Liang Li³, Chiung-Yao Huang⁴, Atallah F Ahmed⁵, Chang-Feng Dai⁶, Yang-Chang Wu^{7

8

9}, Mei-Chin Lu^{10

11}, Chih-Chuang Liaw¹², Jyh-Horng Sheu^{13

14

15

16}

Affiliations

¹ School of Pharmacy, China Medical University, Taichung 404, Taiwan. chchao@mail.cmu.edu.tw.
² Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. chchao@mail.cmu.edu.tw.
³ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. m025020018@student.nsysu.edu.tw.
⁴ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. huangcy@mail.nsysu.edu.tw.
⁵ Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. ccliaw@mail.nsysu.edu.tw.
⁶ Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan. afahmed@ksu.edu.sa.
⁷ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. corallab@ntu.edu.tw.
⁸ Research Center for Natural Products & Drug Development, Kaohsiung Medical University, Kaohsiung 807, Taiwan. corallab@ntu.edu.tw.
⁹ Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan. corallab@ntu.edu.tw.
¹⁰ Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. yachwu@mail.cmu.edu.tw.
¹¹ National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan. yachwu@mail.cmu.edu.tw.
¹² Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. jinx6609@nmmba.gov.tw.
¹³ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.
¹⁴ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. sheu@mail.nsysu.edu.tw.
¹⁵ Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan. sheu@mail.nsysu.edu.tw.
¹⁶ Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.

Abstract

Five new isoprenoids, 3,4,8,16-tetra-epi-lobocrasol (1), 1,15β-epoxy-deoxysarcophine (2), 3,4-dihydro-4α,7β,8α-trihydroxy-Δ²-sarcophine (3), ent-sarcophyolide E (4), and 16-deacetyl- halicrasterol B (5) and ten known compounds 6‒15, were characterized from the marine soft coral Sarcophyton glaucum, collected off Taitung coastline. Their structures were defined by analyzing spectra data, especially 2D NMR and electronic circular dichroism (ECD). The structure of the known compound lobocrasol (7) was revised. Cytotoxicity potential of the isolated compounds was reported, too.

Keywords: ent-sarcophyolide E; lobocrasol; sarcophine; sarcophyton glaucum.

MeSH terms

Animals
Anthozoa / chemistry*
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Circular Dichroism
Humans
Magnetic Resonance Spectroscopy
Terpenes / chemistry
Terpenes / isolation & purification*
Terpenes / pharmacology

Substances

Antineoplastic Agents
Terpenes