Impact of bovine and human serum albumin on Curcumin in vitro activity against Staphylococcus aureus

Sin Yeang Teow; Syed Atif Ali

Impact of bovine and human serum albumin on Curcumin in vitro activity against Staphylococcus aureus

Pak J Pharm Sci. 2017 May;30(3):891-895.

Authors

Sin Yeang Teow¹, Syed Atif Ali¹

Affiliation

¹ Cluster of Oncological and Radiological Sciences, Advanced Medical and Dental Institute (AMDI), University Sains Malaysia (USM), Bertam, Kepala Batas, Pulau Pinang, Malaysia.

PMID: 28653935

Abstract

This study evaluated the impact of pH (7.4 and 6.5), bovine serum albumin (BSA), and human serum albumin (HSA) on Curcumin activity against 2 reference, 1 clinical, and 10 environmental strains of Staphylococcus aureus (S. aureus). Minimal inhibitory concentrations (MICs) of Curcumin against S. aureus were statistically indifferent (p>0.05) at pH7.4 and pH6.5. Activity of Curcumin against S. aureus was reduced by two folds in the presence of 1.25-5% BSA/HSA.

MeSH terms

Animals
Anti-Bacterial Agents / pharmacology
Cattle
Curcumin / pharmacology*
Humans
Hydrogen-Ion Concentration
In Vitro Techniques
Microbial Sensitivity Tests
Serum Albumin / chemistry
Staphylococcus aureus / drug effects

Substances

Anti-Bacterial Agents
Serum Albumin
Curcumin