Examining the importance of laboratory and diagnostic testing when treating and diagnosing onychomycosis

Int J Dermatol. 2018 Feb;57(2):131-138. doi: 10.1111/ijd.13690. Epub 2017 Jun 27.

Abstract

Onychomycosis is a fungal nail infection caused primarily by dermatophytes. Several other nail disorders, including psoriasis, can simulate onychomycosis. Accurate diagnosis is therefore vital for the ongoing treatment and management of onychomycosis and to avoid misdiagnosis and treatment delay, which can be both lengthy and costly. Often, a combination of histologic and laboratory techniques is used to obtain an accurate diagnosis. The potential diagnostic challenges associated with the differential diagnosis of onychomycosis caused by dermatophytes and the most common techniques used to confirm the diagnosis are discussed.

Publication types

  • Review

MeSH terms

  • Benzenesulfonates
  • Biopsy
  • Diagnosis, Differential
  • Fluorescent Dyes
  • Humans
  • Hydroxides
  • Microbiological Techniques
  • Mycology / methods*
  • Nails / microbiology
  • Nails / pathology
  • Onychomycosis / diagnosis*
  • Onychomycosis / drug therapy
  • Onychomycosis / microbiology
  • Onychomycosis / pathology*
  • Periodic Acid-Schiff Reaction
  • Polymerase Chain Reaction
  • Potassium Compounds
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Substances

  • Benzenesulfonates
  • Fluorescent Dyes
  • Hydroxides
  • Potassium Compounds
  • C.I. Fluorescent Brightening Agent 28
  • potassium hydroxide