Predictive Factors for Prolonged Urination Disorder After Permanent 125I Brachytherapy for Localized Prostate Cancer

Abstract

Background: We assessed the change in LUTS after prostate brachytherapy to reveal factors for prolonged urination disorder.

Materials and methods: Four hundred and four patients received prostate brachytherapy at our institution and were followed-up for at least 2 years. We evaluated the correlation of mean IPSS changes and clinical factors. Using multivariate analysis, we also evaluated clinical factors with potential to delay IPSS resolution.

Results: In cases with prostate volume more than 30 cm³, radiation dose to 90% of prostate volume (D90) more than 160 Gy, and radiation dose to 30% of the urethral volume (UD30) more than 240 Gy, mean IPSS levels were significantly higher, even 30 months after treatment. On multivariate analysis, baseline IPSS more than 8 points and D90 more than 160 Gy were significant predictors for delayed IPSS resolution.

Conclusion: Our data suggest that higher baseline IPSS and higher D90 were predictors for prolonged urination disorder.

Keywords: Brachytherapy; lower urinary tract symptoms; prostate cancer.