Aflatoxin B1-induced epigenetic alterations: An overview

Yaqi Dai; Kunlun Huang; Boyang Zhang; Liye Zhu; Wentao Xu

doi:10.1016/j.fct.2017.06.034

Aflatoxin B1-induced epigenetic alterations: An overview

Food Chem Toxicol. 2017 Nov;109(Pt 1):683-689. doi: 10.1016/j.fct.2017.06.034. Epub 2017 Jun 20.

Authors

Yaqi Dai¹, Kunlun Huang², Boyang Zhang¹, Liye Zhu¹, Wentao Xu³

Affiliations

¹ Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, 100083, Beijing, China; Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, 100083, Beijing, China.
² Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, 100083, Beijing, China; Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, 100083, Beijing, China; The Supervision, Inspection and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, 100083, Beijing, China.
³ Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, 100083, Beijing, China; Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, 100083, Beijing, China; The Supervision, Inspection and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, 100083, Beijing, China. Electronic address: xuwentao@cau.edu.cn.

PMID: 28645871
DOI: 10.1016/j.fct.2017.06.034

Abstract

Aflatoxin B1 (AFB1) is widely distributed in nature, especially in a variety of food commodities. It is confirmed to be the most toxic of all the aflatoxins. The toxicity of AFB1 has been well investigated, and it may result in severe health problems including carcinogenesis, mutagenesis, growth retardation, and immune suppression. Epigenetic modifications including DNA methylation, histone modifications and regulation of non-coding RNA play an important role in AFB1-induced disease and carcinogenesis. To better understand the evidence for AFB1-induced epigenetic alterations and the potential mechanisms of the toxicity of AFB1, we conducted a review of published studies of AFB1-induced epigenetic alterations.

Keywords: Aflatoxin B1; DNA methylation; Epigenetics; Histone modifications; Non-coding RNA.

Publication types

Review

MeSH terms

Aflatoxin B1 / toxicity*
Animals
DNA / genetics
DNA / metabolism
DNA Methylation / drug effects
Epigenomics
Histones / genetics
Histones / metabolism
Humans

Substances

Histones
DNA
Aflatoxin B1