Quantitative structure-skin permeability relationships

Toxicology. 2017 Jul 15:387:27-42. doi: 10.1016/j.tox.2017.06.008. Epub 2017 Jun 21.

Abstract

This paper reviews in silico models currently available for the prediction of skin permeability. A comprehensive discussion on the developed methods is presented, focusing on quantitative structure-permeability relationships. In addition, the mechanistic models and comparative studies that analyse different models are discussed. Limitations and strengths of the different approaches are highlighted together with the emergent issues and perspectives.

Keywords: Dermal absorption; Mathematical modelling; Permeability; QSPR; Skin; Stratum corneum.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Cutaneous
  • Animals
  • Databases, Chemical
  • Diffusion
  • Humans
  • Models, Biological*
  • Particle Size
  • Permeability
  • Pharmaceutical Preparations / administration & dosage
  • Pharmaceutical Preparations / chemistry
  • Pharmaceutical Preparations / metabolism*
  • Quantitative Structure-Activity Relationship
  • Skin / anatomy & histology
  • Skin / drug effects
  • Skin / metabolism*
  • Skin Absorption* / drug effects

Substances

  • Pharmaceutical Preparations