Abstract
Heart failure is highly prevalent and is associated with substantial mortality and morbidity, despite the many treatment options currently available. We propose a potential new approach to treating heart disease: promoting cardiogenesis from existing cardiac myocytes by inhibiting the Hippo pathway, a “stop growth” pathway in the heart.
Keywords:
cardiogenesis; heart failure; myocardial infarction; treatment.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Heart / physiology*
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Heart Diseases / metabolism*
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Heart Diseases / pathology
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Heart Diseases / therapy*
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Heart Failure / metabolism
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Heart Failure / pathology
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Heart Failure / therapy
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Hippo Signaling Pathway
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Humans
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Organogenesis / physiology*
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Protein Serine-Threonine Kinases / metabolism*
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Treatment Outcome
Substances
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Protein Serine-Threonine Kinases