Bone marrow hematons: An access point to the human hematopoietic niche

Am J Hematol. 2017 Oct;92(10):1020-1031. doi: 10.1002/ajh.24830. Epub 2017 Jul 29.

Abstract

To understand the complex interactions between hematopoietic stem cells and the bone marrow niche, a human experimental model is needed. Our hypothesis is that hematons are an appropriate ex vivo model of human bone marrow. We analyzed the hierarchical hematopoietic cell content and the tissue organization of single hematons from healthy donors. Most (>90%) hematons contained precursors of all cell lineages, myeloid progenitors, and LTC-ICs without preferential commitment. Approximately, half of the hematons could generate significant levels of lympho-myeloid hematopoiesis after transplantation in an NSG mouse model, despite the low absolute numbers of transplanted CD34+ cells. Mesenchymal STRO-1+ and/or CD271+ cells formed a critical network that preserved hematon cohesion, and STRO-1+ cells colocalized with most hematopoietic CD34+ cells (68%). We observed an influence of age and gender. These structures represent a particularly attractive model for studying the homeostasis of the bone marrow niche and pathological changes that occur during diseases.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Bone Marrow / physiology
  • Bone Marrow / ultrastructure
  • Bone Marrow Cells / cytology*
  • Bone Marrow Cells / physiology
  • Bone Marrow Cells / ultrastructure
  • Cell Communication / physiology
  • Female
  • Flow Cytometry
  • Healthy Volunteers
  • Hematopoiesis / physiology*
  • Hematopoietic Stem Cell Transplantation
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / physiology
  • Hematopoietic Stem Cells / ultrastructure
  • Humans
  • Male
  • Mice
  • Microscopy, Confocal
  • Microscopy, Electron
  • Middle Aged
  • Models, Biological*
  • Transplantation, Heterologous
  • Young Adult