[A role of P-glycoprotein in neurology]

Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(1):67-71. doi: 10.17116/jnevro20171171167-71.
[Article in Russian]

Abstract
in English, Russian

On the basis of the analysis of literature data, the authors show a role of P-glycoprotein in the pathogenesis, pharmacotherapy and a prophylaxis of neurologic diseases (Alzheimer's disease, Parkinson's disease, epilepsy, stroke).

На основе анализа данных литературы показана роль гликопротеина-P в патогенезе, фармакотерапии и профилактике ряда неврологических заболеваний - болезнь Альцгеймера, болезнь Паркинсона, эпилепсия, острое нарушение мозгового кровобращения, тромбоэмболия сосудов головного мозга.

Keywords: ABCB1 protein; MDR1; P-glycoprotein; Parkinson’s disease; epilepsy; stroke.

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / physiology*
  • Alzheimer Disease*
  • Epilepsy*
  • Humans
  • Parkinson Disease*

Substances

  • ABCB1 protein, human
  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1