Gain-of-function SNPs in NLRP3 and IL1B genes confer protection against obesity and T2D: undiscovered role of inflammasome genetics in metabolic homeostasis?

Endocrine. 2018 May;60(2):368-371. doi: 10.1007/s12020-017-1343-0. Epub 2017 Jun 20.

Authors

Juliana de Moraes Rodrigues¹, Dhemerson Souza de Lima¹, Vinicius N C Leal¹, Adriana A Bosco², Valeria Sandrim³, Alessandra Pontillo⁴

Affiliations

¹ Laboratório de Imunogenética, Departamento of Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
² Nucleo de Pos-Graduacao e Pesquisa-Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil.
³ Departmento de Farmacologia, Instituto de Biociencias, Universidade Estadual Paulista/UNESP, Botucatu, SP, Brazil.
⁴ Laboratório de Imunogenética, Departamento of Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo (USP), São Paulo, SP, Brazil. pontillo.a@gmail.com.

PMID: 28634744
DOI: 10.1007/s12020-017-1343-0

No abstract available

Publication types

Letter

MeSH terms

Adaptor Proteins, Signal Transducing / genetics
Apoptosis Regulatory Proteins / genetics
Diabetes Mellitus, Type 2 / genetics*
Female
Gain of Function Mutation
Humans
Inflammasomes / genetics*
Interleukin-18 / genetics
Interleukin-1beta / genetics*
Male
NLR Family, Pyrin Domain-Containing 3 Protein / genetics*
NLR Proteins
Obesity / genetics*
Polymorphism, Single Nucleotide

Substances

Adaptor Proteins, Signal Transducing
Apoptosis Regulatory Proteins
IL18 protein, human
IL1B protein, human
Inflammasomes
Interleukin-18
Interleukin-1beta
NLR Family, Pyrin Domain-Containing 3 Protein
NLR Proteins
NLRP1 protein, human
NLRP3 protein, human

Grants and funding

2015/23395-6/Sao Paulo Research Foundation (FAPESP)/International