Abstract
Sulfonamide is a common structural motif in naturally occurring and synthetic medicinal compounds. The rising interest in sulfonamides and N-acyl derivatives is attested by the large number of drugs and lead compounds identified in last years, explored in different fields of medicinal chemistry and showing biological activity. Many acylsulfonamide derivatives were designed and synthesized as isosteres of carboxylic acids, being the characteristics of these functional groups very close. Starting from chemical routes to N-acylsulfonamides, this review explores compounds of pharmaceutical interest, developed as enzymatic inhibitors or targeting receptors.
Keywords:
PPAR; acylsulfonamides; antiproliferative; bioisosteres; sulfonamides.
© 2017 John Wiley & Sons A/S.
MeSH terms
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Carboxylic Acids / chemistry
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Chemistry, Pharmaceutical
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Drug Design
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / metabolism
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Peroxisome Proliferator-Activated Receptors / agonists
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Peroxisome Proliferator-Activated Receptors / antagonists & inhibitors
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Peroxisome Proliferator-Activated Receptors / metabolism
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Receptors, Prostaglandin E / metabolism
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Structure-Activity Relationship
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Sulfonamides / chemical synthesis
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Sulfonamides / chemistry*
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Sulfonamides / metabolism
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Viral Nonstructural Proteins / chemistry
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Viral Nonstructural Proteins / metabolism
Substances
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Carboxylic Acids
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Enzyme Inhibitors
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NS3 protein, hepatitis C virus
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Peroxisome Proliferator-Activated Receptors
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Receptors, Prostaglandin E
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Sulfonamides
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Viral Nonstructural Proteins