Climate warming causes changes in permafrost distribution, which affects the surface energy balance, hydrologic cycle and carbon flux in cold regions. In this study, the Surface Frost Number model was applied to examine permafrost distribution on the Qinghai-Tibet Plateau (QTP) under the four RCPs (RCP2.6, RCP4.5, RCP6.0, and RCP8.5). The Kappa statistic was used to evaluate model results by comparing simulations of baseline permafrost distribution (1981-2010) with the existing frozen soil maps. The comparison shows that the Surface Frost Number model is suitable for simulating the general characteristics of permafrost distribution on the QTP. Simulated results suggest that areas of permafrost degradation would be the smallest in the near-term (2011‒2040) with the rates of 17.17%, 18.07%, 12.95% and 15.66% under RCP2.6, RCP4.5, RCP6.0 and RCP8.5, respectively. The rate of permafrost degradation would be faster in the mid-term (2041‒2070), especially under the RCP8.5 scenario (about 41.42%). Areas of permafrost degradation would be the largest in the long-term (2071‒2099) relative to baseline conditions, with a modelled 64.31% decrease in permafrost distribution using the RCP8.5 scenario. Our results would help the decision‒making for engineering construction program on the QTP, and support local units in their efforts to adapt climate change.