The effect of estrogen on tendon and ligament metabolism and function

J Steroid Biochem Mol Biol. 2017 Sep:172:106-116. doi: 10.1016/j.jsbmb.2017.06.008. Epub 2017 Jun 16.

Abstract

Tendons and ligaments are crucial structures inside the musculoskeletal system. Still many issues in the treatment of tendon diseases and injuries have yet not been resolved sufficiently. In particular, the role of estrogen-like compound (ELC) in tendon biology has received until now little attention in modern research, despite ELC being a well-studied and important factor in the physiology of other parts of the musculoskeletal system. In this review we attempt to summarize the available information on this topic and to determine many open questions in this field.

Keywords: Estrogen; Musculoskeletal tissues; Tendon cells; Tendons and ligaments.

Publication types

  • Review

MeSH terms

  • Animals
  • Collagen Type I / genetics
  • Collagen Type I / metabolism
  • Estrogen Receptor Modulators / pharmacology*
  • Estrogen Receptor alpha / chemistry
  • Estrogen Receptor alpha / genetics
  • Estrogen Receptor alpha / metabolism
  • Estrogen Receptor beta / chemistry
  • Estrogen Receptor beta / genetics
  • Estrogen Receptor beta / metabolism
  • Female
  • Gene Expression / drug effects
  • Hormone Replacement Therapy / methods
  • Humans
  • Ligaments / drug effects*
  • Ligaments / injuries
  • Ligaments / metabolism
  • Menopause / genetics
  • Ovariectomy
  • Phytoestrogens / pharmacology*
  • Pregnancy
  • Structural Homology, Protein
  • Tendon Injuries / drug therapy*
  • Tendon Injuries / genetics
  • Tendon Injuries / metabolism
  • Tendon Injuries / pathology
  • Tendons / drug effects*
  • Tendons / metabolism
  • Tendons / pathology

Substances

  • Collagen Type I
  • Estrogen Receptor Modulators
  • Estrogen Receptor alpha
  • Estrogen Receptor beta
  • Phytoestrogens