Abstract
Anecdotal case reports, amplified by mass media and internet-based opinion groups, have recently indicated vaccinations as possibly responsible for autoimmunity/lymphoproliferation development. Multiply vaccinated Italian military personnel (group 1, operating in Italy, group 2, operating in Lebanon) were followed-up for nine months to monitor possible post-vaccine autoimmunity/lymphoproliferation onset. No serious adverse event was noticed in both groups. Multivariate analysis of intergroup differences only showed a significant association between lymphocyte increase and tetanus/diphtheria vaccine administration. A significant post-vaccine decrease in autoantibody positivity was observed. Autoantibodies were also studied by microarray analysis of self-proteins in subjects exposed to ≥4 concurrent vaccinations, without observing significant difference among baseline and one and nine months post-vaccine. Moreover, HLA-A2 subjects have been analyzed for the possible CD8T-cell response to apoptotic self-epitopes, without observing significant difference between baseline and one month post-vaccine. Multiple vaccinations in young adults are safe and not associated to autoimmunity/lymphoproliferation onset during a nine-month-long follow-up.
Keywords:
Apoptotic self-epitopes; Autoimmunity; Lymphoproliferation; Microarray analysis; Military personnel; Vaccinations.
Copyright © 2017 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Antibodies, Antineutrophil Cytoplasmic / immunology
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Antibodies, Antinuclear / immunology
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Antibodies, Antiphospholipid / immunology
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Autoantibodies / immunology
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Autoimmune Diseases / epidemiology*
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Autoimmune Diseases / immunology
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Blood Protein Electrophoresis
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Chickenpox Vaccine / therapeutic use
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Diphtheria-Tetanus Vaccine / therapeutic use
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Female
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Follow-Up Studies
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Hepatitis A Vaccines / therapeutic use
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Hepatitis B Vaccines / therapeutic use
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Humans
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Immunoglobulins / blood
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Influenza Vaccines / therapeutic use
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Italy / epidemiology
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Lymphoproliferative Disorders / epidemiology*
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Lymphoproliferative Disorders / immunology
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Male
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Measles-Mumps-Rubella Vaccine / therapeutic use
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Meningococcal Vaccines / therapeutic use
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Military Personnel / statistics & numerical data*
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Poliovirus Vaccine, Inactivated / therapeutic use
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Prospective Studies
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Rheumatoid Factor / immunology
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Risk Factors
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Typhoid-Paratyphoid Vaccines / therapeutic use
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Vaccines / therapeutic use*
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Young Adult
Substances
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Antibodies, Antineutrophil Cytoplasmic
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Antibodies, Antinuclear
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Antibodies, Antiphospholipid
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Autoantibodies
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Chickenpox Vaccine
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Diphtheria-Tetanus Vaccine
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Hepatitis A Vaccines
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Hepatitis B Vaccines
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Immunoglobulins
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Influenza Vaccines
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Measles-Mumps-Rubella Vaccine
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Meningococcal Vaccines
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Poliovirus Vaccine, Inactivated
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Typhoid-Paratyphoid Vaccines
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Vaccines
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anti-extractable nuclear antigen antibodies
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Rheumatoid Factor