Epigenetic Biomarkers and Cardiovascular Disease: Circulating MicroRNAs
Rev Esp Cardiol (Engl Ed). 2017 Sep;70(9):763-769.
doi: 10.1016/j.rec.2017.05.013.
Epub 2017 Jun 13.
[Article in
English,
Spanish]
Affiliations
- 1 Grupo de Lípidos y Patología Cardiovascular, Instituto de Investigación Biomédica Sant Pau (IIB Sant Pau), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: DGonzalo@santpau.cat.
- 2 Departamento de Biología Funcional (Área de Fisiología), Universidad de Oviedo, Asturias, Spain.
- 3 Grupo de Lípidos y Patología Cardiovascular, Instituto de Investigación Biomédica Sant Pau (IIB Sant Pau), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigaciones Biomédicas de Barcelona (IibB), Consejo Superior de Investigaciones Científicas (CSIC), Barcelona, Spain.
Abstract
MicroRNAs (miRNAs) are a class of small noncoding RNA (20-25 nucleotides) involved in gene regulation. In recent years, miRNAs have emerged as a key epigenetic mechanism in the development and physiology of the cardiovascular system. These molecular species regulate basic functions in virtually all cell types, and are therefore directly associated with the pathophysiology of a large number of cardiovascular diseases. Since their relatively recent discovery in extracellular fluids, miRNAs have been studied as potential biomarkers of disease. A wide array of studies have proposed miRNAs as circulating biomarkers of different cardiovascular pathologies (eg, myocardial infarction, coronary heart disease, and heart failure, among others), which may have superior physicochemical and biochemical properties than the conventional protein indicators currently used in clinical practice. In the present review, we provide a brief introduction to the field of miRNAs, paying special attention to their potential clinical application. This includes their possible role as new diagnostic or prognostic biomarkers in cardiovascular disease.
Keywords:
Biomarcadores; Biomarkers; Cardiovascular disease; Enfermedad cardiovascular; MicroARN; MicroRNA.
Copyright © 2017 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.
MeSH terms
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Biomarkers / blood
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Cardiovascular Diseases / blood
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Cardiovascular Diseases / genetics*
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Circulating MicroRNA / blood
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Circulating MicroRNA / genetics*
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Coronary Disease / blood
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Coronary Disease / genetics
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Epigenesis, Genetic / genetics*
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Gene Expression Regulation*
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Heart Failure / blood
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Heart Failure / genetics
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Humans
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MicroRNAs / blood
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MicroRNAs / genetics
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Myocardial Infarction / blood
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Myocardial Infarction / genetics
Substances
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Biomarkers
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Circulating MicroRNA
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MicroRNAs