1 Departments of Anesthesia and Critical Care Medicine and Keenan Research Centre for Biomedical Science of St Michael's Hospital, St. Michael's Hospital, Toronto, ON, Canada, and Department of Anesthesia and Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada;Keenan Research Centre for Biomedical Science of St Michael's Hospital, St. Michael's Hospital, Toronto, ON, Canada;Department of Anaesthesia, National University of Ireland, Galway, Ireland;Departments of Anesthesia and Critical Care Medicine and Keenan Research Centre for Biomedical Science of St Michael's Hospital, St. Michael's Hospital, Toronto, ON, Canada, and Division of Critical Care, Departments of Anesthesia, Physiology and Interdepartmental, University of Toronto, Toronto, ON, Canada.